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Cholera Prevention & Treatment in Nigeria

Understanding Nigeria's recurrent cholera outbreaks and how to protect your family

Cholera is an acute diarrhoeal infection caused by Vibrio cholerae โ€” transmitted through contaminated water and food. Nigeria experiences regular cholera outbreaks, particularly in northern states, during and after flooding, and in areas with inadequate water sanitation and hygiene (WASH). The 2021 Nigerian cholera outbreak was one of the worst in recent years โ€” over 100,000 cases and nearly 3,500 deaths. Cholera is characterised by sudden, profuse, painless watery diarrhoea (known as 'rice water' stools) and vomiting โ€” causing severe dehydration that can be fatal within hours. Yet cholera is both preventable and treatable โ€” with death nearly always avoidable with prompt oral rehydration therapy.

Signs and Symptoms

โœ“ Sudden onset of profuse watery diarrhoea โ€” 'rice water' stools (grey-white, odourless)
โœ“ Rapid volume loss: up to 20 litres per day in severe cases
โœ“ Vomiting (usually without nausea)
โœ“ Rapid progression to severe dehydration: sunken eyes, dry mouth, skin tenting, rapid weak pulse, low blood pressure, reduced urine output
โœ“ Muscle cramps (from electrolyte loss)
โœ“ In severe cases: hypovolemic shock, kidney failure, metabolic acidosis, coma within hours
โœ“ 70โ€“80% of infections are mild or asymptomatic โ€” but infected people still shed bacteria in stool and contaminate water

Risk Factors

When to Seek Help

Sudden profuse watery diarrhoea + vomitingPresume cholera in an outbreak context โ€” start ORS immediately and go to a cholera treatment centre
Signs of severe dehydrationSunken eyes, extreme thirst, inability to speak, no urine output, cold hands โ€” requires immediate IV rehydration
Any dehydration in children under 5Children dehydrate much faster than adults โ€” seek help within 2โ€“3 hours of onset of severe diarrhoea
During a declared cholera outbreakAny acute diarrhoeal illness in the community should be reported to the LGA health department and assessed at a cholera treatment centre
Household contact of a confirmed cholera caseProphylactic doxycycline may be offered during outbreaks. Intensify water and hand hygiene

Tests & Diagnosis

๐Ÿงช Stool culture for Vibrio cholerae
Gold standard โ€” but takes 24โ€“48 hours. Diagnosis is usually clinical during outbreaks, confirmed by culture retrospectively
๐Ÿงช Rapid diagnostic tests (cholera RDT)
Crystal VC or similar dipstick tests โ€” result in 15 minutes. Used in outbreak settings. High sensitivity but limited specificity
๐Ÿงช Electrolytes and creatinine
In severe dehydration โ€” guides IV fluid replacement and monitors for kidney failure
๐Ÿงช Full blood count
Haemoconcentration (raised haematocrit) indicates dehydration severity
๐Ÿงช Blood pressure and pulse
Most important bedside assessment โ€” monitors severity and response to rehydration

Treatment Options

1
Oral rehydration solution (ORS) โ€” life-saving and the cornerstone of treatment
WHO ORS: 1 sachet dissolved in 1 litre of safe water. For mild-moderate dehydration: 50โ€“100mL/kg over 4โ€“6 hours. ORS available free at all PHCs during outbreaks. Homemade: 6 level teaspoons of sugar + 1 level teaspoon of salt in 1 litre of safe water โ€” effective if ORS unavailable
2
IV fluids โ€” for severe dehydration and shock
Ringer's lactate preferred (corrects acidosis). Rapid infusion: 30mL/kg in 30 minutes for adults in shock. Then continue at 10mL/kg/hour. Transition to ORS as patient improves
3
Antibiotics
Doxycycline 300mg single dose (adults) โ€” reduces duration of diarrhoea and cholera excretion. Azithromycin for children and pregnant women. Only for moderate-severe cases โ€” does not replace rehydration
4
Zinc supplementation
Zinc 20mg/day for 10โ€“14 days for children โ€” reduces stool volume and duration
5
Cholera vaccine (Shanchol/Euvichol)
Oral vaccine โ€” 2 doses 2 weeks apart for adults and children > 1 year. Used in outbreak control and for high-risk communities. Reactive mass vaccination campaigns conducted by NCDC/WHO during outbreaks
6
PREVENTION โ€” more important than treatment
Boil or chlorinate all drinking water. Wash hands with soap after toilet and before food. Eat freshly cooked food. Avoid street food during outbreaks. Build and use latrines. Improve drainage around homes before rainy season. Report suspected cases immediately

Frequently Asked Questions

Can I make ORS at home if I can't get to a pharmacy?
Yes. Home ORS: add 6 level teaspoons of sugar (not heaped) and 1 level teaspoon of salt to 1 litre of safe water (boiled and cooled, or bottled water). Stir well. This is very close to WHO ORS composition and is life-saving when commercial sachets are unavailable. Coconut water is a reasonable natural alternative. Never give plain water alone โ€” it worsens the electrolyte imbalance.
Is cholera always fatal?
No โ€” with prompt rehydration, cholera is almost never fatal. The case fatality rate with proper treatment is < 1%. Without treatment, it can reach 25โ€“50%. The challenge in Nigeria is that many people die before reaching a health facility, or delay seeking care. Recognising the symptoms early and starting ORS immediately at home saves lives.
Should I stop eating during cholera?
No โ€” continue feeding as soon as tolerated. Children especially should continue breastfeeding. Restricting food worsens nutritional status and slows recovery. Oral rehydration should be given alongside, not instead of, normal nutrition.
How do I protect my family during a cholera outbreak?
1. Drink only water that has been boiled for 1 minute or treated with water purification tablets (sodium hypochlorite โ€” 2 drops per litre, wait 30 minutes). 2. Wash hands with soap and water (or hand sanitiser) after toilet and before handling food. 3. Eat only freshly cooked food. 4. Avoid buying food from street vendors during outbreaks. 5. Dispose of faeces safely โ€” use a latrine, not open ground. 6. Report any suspected cholera case to the nearest health facility immediately.

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