Genotype Result Meaning — AA, AS, SS and What It Means for You

Your genotype describes which haemoglobin genes you carry — one from each parent. In Nigeria this result carries weight beyond medicine, because it determines the risk of sickle cell disease in your children. It is worth understanding properly rather than second-hand.

Reference ranges

AANormal haemoglobin — no sickle gene
ASSickle cell trait — a carrier, generally healthy
SSSickle cell disease — requires ongoing care
AC / SCLess common variants; SC behaves as a milder sickling disease

Reference ranges vary between laboratories and methods. Always read your result against the range printed on your own report.

Seek care urgently if

What a high result can mean

AS (trait)

You are healthy but carry one sickle gene. Only rarely causes symptoms — at extreme altitude or severe dehydration.

SC

A form of sickling disease, generally milder than SS but needing follow-up.

SS

Sickle cell disease, needing lifelong specialist care.

What a low result can mean

AA

No sickle gene, and no risk of passing one on.

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What happens next

For couples: AA + anything is safe. AS + AS carries a 1-in-4 chance of SS with each pregnancy. AS + SS carries a 1-in-2 chance. Knowing both genotypes before marriage or pregnancy is the point of testing, and genetic counselling is available where the combination carries risk.

Blood Group & Genotype Full Blood Count Premarital Screening

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This page explains what a result can mean in general terms. It is not a diagnosis and cannot account for your history, medication or examination. All visits to Mascot Healthcare are by appointment — Mon–Sat, 9AM–5PM, 52 Sholanke Street, Akoka, Yaba, Lagos.