Quick answer: When both partners are AS, each pregnancy has a 1 in 4 chance of a child with sickle cell disease (SS), a 1 in 2 chance of a child who is AS, and a 1 in 4 chance of a child who is AA. These chances are the same for every pregnancy. Couples have real options, and the right choice is a personal one, best made with good information.
First, confirm both genotypes
Make sure both results are reliable. If you've had two results that disagree, or a blood transfusion in the last 3 months, repeat the test. See our genotype test.
Your chances with each pregnancy
| Child's genotype | Chance in each pregnancy |
|---|---|
| AA | 1 in 4 |
| AS (carrier, healthy) | 1 in 2 |
| SS (sickle cell disease) | 1 in 4 |
"1 in 4" doesn't mean one child in every four. Every pregnancy is a fresh 1 in 4 chance.
The options couples consider
- Genetic counselling: a calm, detailed talk about what the results mean for you. It's a good first step for any AS couple.
- Testing during pregnancy: specialist centres can test the baby's genotype early in pregnancy, using a sample from the placenta (CVS) or the fluid around the baby (amniocentesis). Couples then decide what to do with that information. Some may choose to terminate the pregnancy.
- IVF with genetic testing of embryos (PGT): some fertility centres in Lagos offer this, so that only embryos without SS are transferred. It's expensive and takes time.
- Other paths to parenthood, such as adoption.
- Going ahead naturally, knowing the chances.
Get tested in Akoka, Lagos
The genotype test is walk-in at Mascot Healthcare, 52 Sholanke Street, off Chemist Junction, Akoka, Lagos, Monday to Saturday, 9 AM to 5 PM. See also our premarital screening. Prices are on our price list.
This article is general information, not medical advice for your situation.