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๐Ÿ‘ถ Men's Health

HIV and Pregnancy โ€” Preventing Mother-to-Child Transmission

How HIV-positive mothers can have HIV-negative babies in Nigeria

Mother-to-child transmission (MTCT) of HIV โ€” also called vertical transmission โ€” can occur during pregnancy, labour and delivery, or breastfeeding. Without treatment, the risk of transmission is 15โ€“45%. With optimal antiretroviral therapy and appropriate feeding practices, transmission can be reduced to less than 1%. Nigeria has made significant progress through its Prevention of Mother-to-Child Transmission (PMTCT) programme, but gaps remain: late ANC booking, stock-outs of supplies, poor follow-up, and mixed feeding practices continue to result in preventable infections in newborns.

Signs and Symptoms

โœ“ HIV-positive pregnancy is not detected by symptoms โ€” routine testing at ANC is essential
โœ“ All pregnant women should be tested for HIV at their first ANC visit (opt-out testing)
โœ“ Women who test negative but are at risk should be retested in the third trimester and at delivery
โœ“ Signs of AIDS in pregnancy (late, untreated HIV): weight loss, oral thrush, persistent cough
โœ“ Newborn HIV infection: pneumonia, failure to thrive, oral thrush โ€” usually apparent by 6โ€“8 weeks

Risk Factors

When to Seek Help

Immediately on discovering pregnancyBook ANC early and test for HIV. If positive, start ART on the same day or within days
If already on ART and become pregnantDo not stop ART โ€” continue immediately. Regimen review may be needed for pregnancy safety
Any signs of illness in HIV-positive pregnancyFever, cough, diarrhoea, weight loss โ€” opportunistic infections are more dangerous in pregnancy and need prompt treatment
At deliveryInform the delivery team of HIV status so appropriate newborn prophylaxis can be given immediately (within 6โ€“12 hours of birth)
At 4โ€“6 weeks after delivery (infant)Infant HIV PCR (DNA) test at 4โ€“6 weeks of age โ€” standard of care in Nigeria PMTCT programme

Tests & Diagnosis

๐Ÿงช Maternal HIV test at first ANC
All pregnant women โ€” opt-out testing. Reactive result confirmed with second rapid test
๐Ÿงช Maternal viral load
At ART start and at 34โ€“36 weeks โ€” high viral load near delivery informs decision about caesarean section
๐Ÿงช CD4 count
At diagnosis โ€” guides prophylaxis decisions and opportunistic infection risk
๐Ÿงช Infant HIV DNA PCR
At 4โ€“6 weeks of age (not standard antibody test โ€” maternal HIV antibodies persist in baby until 18 months, making antibody tests unreliable early)
๐Ÿงช Infant HIV test at 9 months
Second PCR test โ€” especially important if breastfed
๐Ÿงช Final HIV antibody test at 18 months
Confirms HIV-negative status once maternal antibodies have cleared

Treatment Options

1
Maternal ART โ€” most important intervention
All HIV-positive pregnant women start lifelong ART regardless of CD4 count. Standard regimen: TDF + 3TC + DTG (dolutegravir now recommended in pregnancy). Started at diagnosis or continued if already on ART
2
Infant prophylaxis (NVP)
Newborn receives nevirapine syrup from birth โ€” duration depends on feeding method and maternal viral load. Low risk: NVP for 6 weeks. High risk: NVP for 12 weeks
3
Mode of delivery
Vaginal delivery is safe if viral load < 1000 copies/mL at 36 weeks. Caesarean section may reduce transmission risk if viral load is detectable near delivery
4
Infant feeding
WHO recommends breastfeeding with maternal ART (or infant NVP) for 12โ€“24 months. Mixed feeding (any formula while breastfeeding) must be avoided โ€” it dramatically increases MTCT risk through gut inflammation
5
Cotrimoxazole for baby
Baby starts cotrimoxazole (Septrin) at 4โ€“6 weeks and continues until HIV is definitively excluded โ€” prevents PCP pneumonia if baby is infected
6
Virological testing and early ART for infected infants
If infant tests positive, ART started immediately โ€” infants not treated have 50% mortality by age 2

Frequently Asked Questions

If I'm positive, will my baby definitely get HIV?
With proper treatment, almost certainly not. With optimal ART throughout pregnancy and breastfeeding, and infant prophylaxis, the risk of transmission is less than 1%. The vast majority of HIV-positive mothers in Nigeria who receive PMTCT care have HIV-negative babies.
Can I breastfeed if I'm HIV positive?
Yes โ€” this is the WHO and Nigerian government recommendation. Breastfeeding with maternal ART (ensuring undetectable viral load) is safer than formula feeding in a Nigerian context where clean water access, poverty, and other infections make formula-fed infants more vulnerable. Mixed feeding (breast + formula) is the worst option and must be strictly avoided.
What if I only found out I was HIV positive during labour?
You can still receive a single dose of nevirapine (sdNVP) during labour, and the baby receives nevirapine syrup from birth. This emergency regimen significantly reduces transmission even when started late. Start lifelong ART as soon as possible after delivery.
Will my partner need to be tested?
Yes. Partner HIV testing is strongly recommended โ€” for the partner's own health and to identify whether they need treatment or PrEP. Couples counselling is available at all PMTCT sites. If the partner tests negative, they may be eligible for PrEP.

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